evaluation of long stress-induced non-coding transcripts 5 polymorphism in iranian patients with bladder cancer

background: bladder cancer (bc) is the most commonly diagnosed genitourinary cancer in iran, presented in both men and women. bc is a multifactorial trait resulting from the complex interaction between several genes and environmental factors. long stress-induced non-coding transcript 5 (lsinct5), a member of the long non-coding rnas, is abundantly expressed in high proliferative cells, as well as the cells vulnerable to cellular stress in response to chemical carcinogens. this case-control study aimed to determine any association between lsinct5 rs2962586 polymorphism and bladder cancer. materials and methods: a group of 150 patients with bc were compared with 143 subjects as a control group. genotyping of the rs2962586 polymorphism was done using tetra- primer amplification refractory mutation system-polymerase chain reaction (t-arms pcr) method. results: genotype and allele distribution were not significantly different between the case and control groups. smoking was found to be the confounding risk factor for bladder cancer. conclusion: considering the result of our analyses, it seems that lsinct5 could not affect individual susceptibility to bc among iranian patients, however, it can be considered as a disease predictor among smokers.